Subject: Reaction to Duesberg Reaction to Dr. Peter Duesberg's Theory That HIV is Not the Cause of AIDS See also "Retroviruses and Reality" in READING MATTER for details of Dr. Duesberg's theory. Researchers spoken to for this piece have extremely high regard for Duesberg and believe he raises appropriate, important questions that deserve debate. Dr. Michael Lange, an infectious disease specialist at the St. Luke's-Roosevelt Hospital in New York, says: "[Duesberg] is a very senior person in this field ... he's got a very distinguised record in the retrovirus <27> field at least to the early 70s if not late 60s, by many people he's considered a much more senior person in the retrovirus field than Bob Gallo <41> is ... When somebody of [Duesberg's] calibre writes a very serious scientific paper coming up with a hypothesis that he feels he cannot accept that, based on the present evidence, HIV <17> by itself causes AIDS I think what we need is an open discussion. But, we haven't seen this ... and that's what I cannot understand." Dr. Michael Davis, the director of clinical studies for the Federal Centre for AIDS in Ottawa, says: "I personally have never said publicly ... that [HIV] causes [AIDS]. I'm an agnostic in the sense that I look at the evidence for anything no matter what it is... [HIV is] a working hypothesis for the time being. It might be more and more strongly confirmed as time goes on. It may be less and less confirmed. Maybe, just maybe, it'll be a red herring." Jim Warner is the senior policy analyst in the Office of Policy Development in the White House. He's taking Duesberg seriously. "I remain unconvinced of whether or not HIV is the cause of [AIDS]," he says. "People get angry when I bring [Duesberg's questions] up. People do not become angry over scientific fact. The fact that people get angry is, to me, a sign something is wrong ... I'm troubled by the questions raised by Dr. Duesberg that are not being answered by Dr. Gallo <41> or anyone else." The general feeling among researchers is that while Duesberg is right to point to possible cofactors <11> in the search for an AIDS cause he goes too far in dismissing HIV altogether. Dr. George Post is the vice president of worldwide research and preclinical development for the SmithKline Beckman Corporation, a multinational pharmaceutical house that is on the trail of an AIDS vaccine. Post recently did a comprehensive survey of AIDS studies to determine if his firm was on the right track. Says Post: "I think the central issue raised by Duesberg is how can a virus that's apparently only present in such a small percentage of cells really cause such profound damage in the immune system when you should be able to replace that number of cells quite rapidly ... He's gone so far as to say that HIV has nothing to do with AIDS at all. I certainly don't buy that." While Post is a strong believer that HIV causes AIDS, he thinks that, paradoxically, the virus needs the help of a body's immune system to cause death - that, in fact, the immune system is a cofactor in causing AIDS. <11> In his view the syndrome's victims are the losers of an immunological lottery. See <38> for Post's theory on autoimmune reactions and AIDS. Dr. Leonard Rosenthal is an associate professor of microbiology and pediatrics at the Georgetown Medical Centre in Washington. He believes that there are a number of things about HIV as the sole cause of AIDS that don't make sense. Rosenthal can't understand why female prostitutes can test AIDS antibody positive <5> but rarely get AIDS while promiscuous male homosexuals are at high risk <4>. He believes that while HIV is important in AIDS there must be other cofactors <11> present before full blown AIDS emerges. See <37> for Rosenthal's theory of what causes AIDS. Dr. Ken Rosenthal (no relation) an associate professor in molecular virology and immunology at McMaster University, thinks that though Duesberg raises important points that should be debated, it's vitally important not to lose sight of HIV as the major cause, the bad guy in AIDS. "I think [Duesberg is] raising valid questions and I think they'll all be resolved in time. I think what the shakeout will be is that HIV is the essential cause although there probably will be cofactors <11> involved," he said.