Subject: Investors Snap Up Biotech Shares Date: Published: 11/12/91 (59 lines) Source: Wall Street Journal. Copyright Dow Jones & Co. Inc. OTC Focus: Composite Index Rises to Another Record As Investors Snap Up Biotech Shares ---- By Anne Newman Staff Reporter of the Wall Street Journal NEW YORK -- Over-the-counter stocks hit their third consecutive record in subdued Veterans Day trading as investors continued to pour money into biotechnology stocks. Immune Response jumped 3 1/4 to 60 3/4, Centocor vaulted 4 1/2 to 49 1/4, Immunex leaped 4 1/2 to 57 3/4, Synergen climbed 2 5/8 to 68, and Amgen gained 1 1/2 to 59. Their rise helped lift the Nasdaq Composite Index to yet another high of 550.71, up 2.63 for a 0.48% gain. Advancing stocks continued to outweigh decliners, 1,039 to 947, as volume fell to a quiet 153.6 million shares from 211.4 million shares Friday. Highflying Immune Response, which has soared more than 21 times its year-end close of 2 7/8, climbed yet again in advance of a Food and Drug Administration advisory panel meeting today to discuss certain yardsticks for approving AIDS-related vaccines. But Merrill Lynch biotechnology analyst Stuart Weisbrod warned in an interview that the stock's astounding rise leaves the development company with little margin for error. Immune Response is developing a vaccine for patients who test positive for the HIV that causes AIDS. Word of an FDA meeting to discuss criteria for approving such vaccines first drove shares of the Carlsbad, Calif., company sharply higher nearly two weeks ago. In an interview, Immune Response's chief executive officer and president, James B. Glavin, played down the importance of the meeting, and attributed yesterday's jump in the stock to general enthusiasm for biotech shares. The meeting, he explained, is more of a data-gathering workshop among a number of participants who will discuss certain criteria for approving AIDS-related vaccines, rather than a meeting where final recommendations will be made. Immune Response just entered a final phase of tests on humans that is expected to last a year, and isn't expected to have any product sales until at least 1993. But Merrill Lynch's Mr. Weisbrod cautioned that investors already seem to be anticipating that the company's vaccine will work, although it still has another crucial round of testing to go. If Immune Response does have a successful, early-stage vaccine, he said, "then the stock is cheap." But if it doesn't work, he cautioned, "this stock could go to 10." Elsewhere among biotechnology shares, he attributed sharp price moves to slow trading, which often exacerbates stock-price moves. [This article is made available here by Dow Jones Co. for the personal and non-commercial use of callers to this bbs, in the hope that it will be of some help to those who are suffering from the disease and others who are seeking to help them.]